QualityDipStocks / Health Care · Pharmaceuticals
Spyre Therapeutics SYRE
Outside our quality screen, so we don’t track its dips. It’s 12% below its 52-week high.
Outside our quality screen, 11% over its Market Value. No fair value estimate for now: there isn’t enough data.
- Fair value est.
- n/a
- Market Value
- $86.36price +11%
- Off 52-wk high
- −12%
- Risk vs market
- Highbeta 1.80
0 bullish · 5 bearish See why
Valuation
What we estimate it's worth, and how it ranks on value vs every stock we cover.
Fair value estimate
No estimate for SYRE: Capital spending isn't tagged for the latest period in SEC XBRL data. We’d rather show nothing than a made-up number.
Risk vs market
How risk vs market is measured
One year of daily returns (Oct 31 to Nov 2, 252 sessions). Beta = how much SYRE moved for each 1% move in the S&P 500 (SPY); 1.0 moves with the market. Volatility is the yearly standard deviation of daily returns. Past behavior, not a forecast.
Swings much more than the market, and its own price swings are 5.2× the S&P 500’s.
- Beta vs S&P 500
- 1.80
- Volatility
- 66% vs 13% SPY
- Correlation SPY
- 0.35
- Correlation QQQ
- 0.34
Valuation details
MV $86.36
Fundamentals
The business itself: sales, profits, cash and debt, from SEC filings.
Bull vs bear
Rule-based from the data on this page, strongest first. Not advice.
Top bullish points 0 of 5
Nothing in our data makes a clear bull case right now.
Top bearish points 5 of 5
ProfitabilityLost $155M over the last 12 months (net income, SEC filings).
ProfitabilityReturn on equity of −25%, below the 6.8% median for the 210 Health Care companies we cover.
ValuationPrice / book of 14.0×, above the 5.2× median for the 217 Health Care companies we cover.
QualityDoesn’t pass our quality screen: no positive free cash flow; ROE under 12% and ROIC under 10%; no sales-growth data.
ValuationTrades 10.6% above its Market Value of $86.36, the average price paid since the Oct 7 filing.
All fundamentals
ROE -25%
Valuation
- P/E
- n/aloss over the last 12 months
- Price / FCF
- n/anot reported in its SEC filings
- FCF yield
- n/anot reported in its SEC filings
- EV / EBITDA
- n/aD&A or debt not tagged in SEC data
- Price / sales
- n/anot reported in its SEC filings
- Price / book
- 13.98×
- Market cap
- $10.0Blisted
- Enterprise value
- n/anot reported in its SEC filings
Growth
- Revenue, 12 months
- $0
- Sales growth, 12 months
- n/ano year-ago 12-month revenue
- Sales growth, 3 yrs
- n/anot reported in its SEC filings
- Diluted EPS, 12 months
- n/anot reported in its SEC filings
- EPS growth, last FY
- n/afewer than two years of diluted EPS
- Net income, 12 months
- −$155M
- Net income growth
- n/anot reported in its SEC filings
Profitability
- Gross margin
- n/agross profit isn't reported (common for service and financial companies)
- Operating margin
- n/anot reported in its SEC filings
- Net margin
- n/anot reported in its SEC filings
- FCF margin
- n/anot reported in its SEC filings
- Return on equity
- −25%
- Return on invested capital
- n/aoperating income, debt, equity or cash not tagged
Balance sheet
- Cash & short-term inv.
- $757M
- Total debt
- n/anot reported in its SEC filings
- Net cash
- n/acash or debt not tagged in SEC data
- Debt / equity
- n/adebt or equity not tagged in SEC data
- Interest coverage
- n/ainterest expense not tagged in SEC data
Cash flow & returns
- Free cash flow, 12 months
- n/anot reported in its SEC filings
- FCF growth, 12 months
- n/anot reported in its SEC filings
- Dividend yield
- 0%
- Payout ratio
- n/anot reported in its SEC filings
- Buybacks, 12 months
- n/anot reported in its SEC filings
- Share count, 1 year
- n/ano quarterly diluted share count
- Stock-based comp
- $38M
Trailing 12 months to Dec 31, 2025; balance sheet at Dec 31, 2025. From Spyre Therapeutics’s SEC filings. Sparklines show up to six fiscal years. n/a means we don’t hold that number, with the reason. How each is computed.
The business
- Gross margin0%
- Operating margin0%
- Return on equity−23%
Chart & levels
Where the price is vs its key levels and trends.
Key levels
Every level vs today’s $95.51
- 52-wk lowlowest close, 1 year$22.18−76.8%
- Market Valueavg paid since Oct 7$86.36−9.6%
- PriceMon Nov 2 close$95.51you are here
- 52-wk highhighest close, 1 year$108.92+14.0%
Momentum & 52-week range
RSI 57 · 5 days +2.8%
Signals
Reversal signal setups, the public ledger and the next earnings date.
Setup & signals
No setup armed
No setup armed, so there’s no trigger or stop to track yet. Reversal signal rules only run on companies that pass our quality screen.
Next report
Nov 3
- DateTue Nov 3
- Consensus EPS($0.79)
- Year-ago EPS($0.15)
- QuarterSep/2026
From Nasdaq’s earnings calendar. A report resets Market Value.
SYRE is outside our quality screen
One text when a published rule fires on one of the 332 quality companies we track: the ticker, the price, the stop and a link to the numbers. Nothing else.
Voices & buzz
Who is talking about it, and how it compares with peers.
Who’s talking about it
Notable investors, executives, analysts and public figures on Spyre Therapeutics in the last 48 hours. Headlines as published, each linked. Their words, not ours.
No notable mentions in the last 48 hours. Checked Nov 3, 1:01 PM ET.
Compare with peers
Closest in size in Pharmaceuticals
Information only, not investment advice. Fair value estimates and talking points are rule-based model output from public data and can be wrong; stop levels are reference points, not orders. How every number is computed.